Mathematical investigation of IP3-dependent calcium dynamics in astrocytes

  title={Mathematical investigation of IP3-dependent calcium dynamics in astrocytes},
  author={Gregory Handy and Marsa Taheri and John A. White and Alla Borisyuk},
  journal={Journal of Computational Neuroscience},
We study evoked calcium dynamics in astrocytes, a major cell type in the mammalian brain. Experimental evidence has shown that such dynamics are highly variable between different trials, cells, and cell subcompartments. Here we present a qualitative analysis of a recent mathematical model of astrocyte calcium responses. We show how the major response types are generated in the model as a result of the underlying bifurcation structure. By varying key channel parameters, mimicking blockers used… CONTINUE READING