Mathematical analysis of perifusion data: models predicting elution concentration.

  title={Mathematical analysis of perifusion data: models predicting elution concentration.},
  author={W. R. Smith and G. Wake and J. Mcintosh and R. McIntosh and M. Pettigrew and R. Kao},
  journal={The American journal of physiology},
  volume={261 1 Pt 2},
  • W. R. Smith, G. Wake, +3 authors R. Kao
  • Published 1991
  • Chemistry, Medicine
  • The American journal of physiology
  • System models are constructed and analyzed for combined convective flow and for dispersion in distorting concentrations of a chemical signal as it passes through a packed column. We derive general analytical solutions for these models. The results have applications to analyses such as in biological experiments involving hormonal stimulation of perifused cells, elution chromatography, adsorption columns, and studies of groundwater flow. The models reveal that the column distorts an incoming… CONTINUE READING
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