Mathematical analysis of multiscale models for hepatitis C virus dynamics under therapy with direct-acting antiviral agents.

@article{Rong2013MathematicalAO,
  title={Mathematical analysis of multiscale models for hepatitis C virus dynamics under therapy with direct-acting antiviral agents.},
  author={Libin Rong and Alan S. Perelson},
  journal={Mathematical biosciences},
  year={2013},
  volume={245 1},
  pages={
          22-30
        }
}
Chronic hepatitis C virus (HCV) infection remains a world-wide public health problem. Therapy with interferon and ribavirin leads to viral elimination in less than 50% of treated patients. New treatment options aiming at a higher cure rate are focused on direct-acting antiviral agents (DAAs), which directly interfere with different steps in the HCV life cycle. In this paper, we describe and analyze a recently developed multiscale model that predicts HCV dynamics under therapy with DAAs. The… CONTINUE READING
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Mathematical modeling of HCV infection: what can it teach us in the era of direct antiviral agents

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