Mathematical analysis of dynamics of cardiac memory and accommodation: theory and experiment.

@article{Watanabe2002MathematicalAO,
  title={Mathematical analysis of dynamics of cardiac memory and accommodation: theory and experiment.},
  author={Mari A. Watanabe and Marcus L. Koller},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2002},
  volume={282 4},
  pages={H1534-47}
}
Decreasing the slope of the dynamic, but not conventional, restitution curves is antifibrillatory. Cardiac memory/accommodation underlies the difference. We measured diastolic interval (DI) and action potential duration (APD) in epicardial, endocardial, and Purkinje tissue from eight dogs. Consecutive 100-stimulus trains were given to study transitions between basic cycle lengths (BCL) ranging from 400 to 1,300 ms. (DI,APD) pairs aligned immediately on the line DI + APD = BCL (64/67) or… CONTINUE READING
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