Mathematical analysis of a proposed mechanism for oscillatory insulin secretion in perifused HIT-15 cells.

Abstract

Oscillatory secretion of insulin has been observed in many different experimental preparations ranging from pancreatic islets to the whole pancreas. Here we examine the mathematical features underlying a possible model for oscillatory secretion from the perifused, insulin-secreting cell line, HIT-15. The model includes the kinetics of uptake of glucose by… (More)

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