Mathematical Modelling of Cell-Fate Decision in Response to Death Receptor Engagement

@inproceedings{Calzone2010MathematicalMO,
  title={Mathematical Modelling of Cell-Fate Decision in Response to Death Receptor Engagement},
  author={Laurence Calzone and Laurent Tournier and Simon Fourquet and Denis Thieffry and Boris Zhivotovsky and Emmanuel Barillot and Andrei Yu. Zinovyev},
  booktitle={PLoS Computational Biology},
  year={2010}
}
Cytokines such as TNF and FASL can trigger death or survival depending on cell lines and cellular conditions. The mechanistic details of how a cell chooses among these cell fates are still unclear. The understanding of these processes is important since they are altered in many diseases, including cancer and AIDS. Using a discrete modelling formalism, we present a mathematical model of cell fate decision recapitulating and integrating the most consistent facts extracted from the literature… CONTINUE READING