Mathematical Modeling of PDGF-Driven Glioblastoma Reveals Optimized Radiation Dosing Schedules

@article{Leder2014MathematicalMO,
  title={Mathematical Modeling of PDGF-Driven Glioblastoma Reveals Optimized Radiation Dosing Schedules},
  author={Kevin Leder and Ken L. Pitter and Quincey Laplant and D Hambardzumyan and Brian D. Ross and Timothy A. Chan and Eric C Holland and Franziska Michor},
  journal={Cell},
  year={2014},
  volume={156},
  pages={603-616}
}
Glioblastomas (GBMs) are the most common and malignant primary brain tumors and are aggressively treated with surgery, chemotherapy, and radiotherapy. Despite this treatment, recurrence is inevitable and survival has improved minimally over the last 50 years. Recent studies have suggested that GBMs exhibit both heterogeneity and instability of differentiation states and varying sensitivities of these states to radiation. Here, we employed an iterative combined theoretical and experimental… CONTINUE READING

From This Paper

Topics from this paper.
50 Citations
68 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 68 references

Radiobiology for the Radiologist (Philadelphia

  • E. J. Hall, A. J. Giaccia
  • 2012
Highly Influential
5 Excerpts

Human cortical

  • T. N. Ignatova, V. G. Kukekov, E. D. Laywell, O. N. Suslov, F. D. Vrionis, D. A. Steindler
  • GLIAL
  • 2002
Highly Influential
1 Excerpt

Similar Papers

Loading similar papers…