Mathematical Formalism for the Properties of Four Basic Models of Indirect Pharmacodynamic Responses

@article{Krzyzanski1997MathematicalFF,
  title={Mathematical Formalism for the Properties of Four Basic Models of Indirect Pharmacodynamic Responses},
  author={Wojciech Krzyzanski and William J. Jusko},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1997},
  volume={25},
  pages={107-123}
}
Four basic models for characterizing indirect pharmacodynamic responses were proposed previously and applied using differential equations. These models consider inhibition or stimulation by drug of the production or loss of mediators or response variables. This report develops partially integrated solutions for these models which allow more detailed examination of the roles of model parameters and pharmacokinetic functions in affecting the time course of drug effects. Because of the nonlinear… CONTINUE READING

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Elementary Differential Equations with Applications

  • C. H. Edwards, D. E. Penney
  • 1994

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