Math6 expression during kidney development and altered expression in a mouse model of glomerulosclerosis.

@article{Ross2006Math6ED,
  title={Math6 expression during kidney development and altered expression in a mouse model of glomerulosclerosis.},
  author={Michael David Ross and Scott Martinka and Amitava Mukherjee and John R Sedor and Charles Vinson and Leslie A. Bruggeman},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2006},
  volume={235 11},
  pages={3102-9}
}
Math6 is a tissue-restricted member of the Atonal family of basic helix-loop-helix (bHLH) transcription factors and has been implicated in specification and differentiation of cell lineages in the brain. We identify here Math6 as a podocyte-expressed bHLH protein that was down-regulated in human immunodeficiency virus-associated nephropathy (HIVAN); a collapsing glomerulopathy characterized by podocyte dedifferentiation. Early in metanephric development, Math6 was expressed in metanephric… CONTINUE READING

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