Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo.

@article{Kawamoto2003Math1GT,
  title={Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo.},
  author={Kohei Kawamoto and Shin-ichi Ishimoto and Ryosei Minoda and D. Brough and Yehoash Raphael},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 11},
  pages={4395-400}
}
Hair cell loss in the mammalian cochlea is irreversible and results in permanent hearing loss. Math1, the basic helix-loop-helix transcription factor homolog of the Drosophila atonal gene, is a positive regulator of hair cell differentiation during cochlear development. Developing hair cells express Math1, and nonsensory cells do not. We set out to determine the outcome of overexpression of Math1 in nonsensory cells of the cochlea on the phenotype of these cells. We demonstrate that in vivo… CONTINUE READING

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