Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal.

@article{Longo2002MaternallyTS,
  title={Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal.},
  author={Letizia Longo and Olga Camacho Vanegas and Meghavi N. Patel and Vittorio Rosti and Haiqing Li and John Waka and Taha Merghoub and Pier Paolo Pandolfi and Rosario Notaro and Katia Manova and Lucio Luzzatto},
  journal={The EMBO journal},
  year={2002},
  volume={21 16},
  pages={4229-39}
}
Mouse chimeras from embryonic stem cells in which the X-linked glucose 6-phosphate dehydrogenase (G6PD) gene had been targeted were crossed with normal females. First-generation (F(1)) G6PD(+/-) heterozygotes born from this cross were essentially normal; analysis of their tissues demonstrated strong selection for cells with the targeted G6PD allele on the inactive X chromosome. When these F(1) G6PD(+/-) females were bred to normal males, only normal G6PD mice were born, because: (i) hemizygous… CONTINUE READING