Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis.

  title={Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis.},
  author={Delphine Payros and Thomas Secher and Mich{\`e}le Boury and Camille Br{\'e}hin and Sandrine M{\'e}nard and Christel Salvador-Cartier and Gabriel Cuevas-Ramos and Claude Watrin and Ingrid Marcq and J P Nougayr{\'e}de and Damien Dubois and Antoine B{\'e}du and Fabien Garnier and Olivier Clermont and Erick Denamur and Pascale Plaisanci{\'e} and Vassilia Th{\'e}odorou and Jean Fioramonti and Ma{\"i}wenn Olier and E. T. Oswald},
  journal={Gut microbes},
  volume={5 3},
The neonatal gut is rapidly colonized by a newly dominant group of commensal Escherichia coli strains among which a large proportion produces a genotoxin called colibactin. In order to analyze the short- and long-term effects resulting from such evolution, we developed a rat model mimicking the natural transmission of E. coli from mothers to neonates. Genotoxic and non-genotoxic E. coli strains were equally transmitted to the offspring and stably colonized the gut across generations. DNA damage… CONTINUE READING

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