Maternal vitamin A supplementation and lung function in offspring.

  title={Maternal vitamin A supplementation and lung function in offspring.},
  author={William Checkley and Keith P West and Robert A. Wise and Matthew R. Baldwin and Lee Shu-Fune Wu and Steven C. LeClerq and Parul Christian and Joanne Katz and James M. Tielsch and Subarna K. Khatry and Alfred Sommer},
  journal={The New England journal of medicine},
  volume={362 19},
BACKGROUND Vitamin A is important in regulating early lung development and alveolar formation. Maternal vitamin A status may be an important determinant of embryonic alveolar formation, and vitamin A deficiency in a mother during pregnancy could have lasting adverse effects on the lung health of her offspring. We tested this hypothesis by examining the long-term effects of supplementation with vitamin A or beta carotene in women before, during, and after pregnancy on the lung function of their… 

Supplementation with vitamin A early in life and subsequent risk of asthma

Vitamin A supplementation early in life was not associated with a decreased risk of asthma in an area with chronic vitamin A deficiency, and being born to mothers who received vitamin A, &bgr;-carotene or placebo before, during and after pregnancy was found to be normal.

Vitamin C supplementation for pregnant smoking women and pulmonary function in their newborn infants: a randomized clinical trial.

Newborns of women randomized to vitamin C, compared with those randomized to placebo, had improved pulmonary function as measured by TPTEF:TE and decreased wheezing through 1 year in the offspring.

Vitamin A and D intake in pregnancy, infant supplementation, and asthma development: the Norwegian Mother and Child Cohort.

Excess vitamin A intake during pregnancy was associated with increased risk of asthma in school-age children, whereas vitamin D intake close to recommendations wasassociated with a reduced risk of asthmatic children and no association for high intakes of both nutrients suggests antagonistic effects of vitamins A and D.

Vitamin A and Pregnancy: A Narrative Review

An extensive review of the literature was conducted to identify conflicting or incomplete data on the topic as well as any gaps in existing data, and recommend routine prenatal vitamin A supplementation for the prevention of maternal and infant morbidity and mortality.

Effect of Vitamin A status during pregnancy on maternal anemia and newborn birth weight: results from a cohort study in the Western Brazilian Amazon

Poor serum retinol status throughout pregnancy was associated with maternal anemia at delivery in Amazonian women, and the current World Health Organization protocols for supplementation during antenatal care should consider VA status for planning recommendations in different scenarios.

Vitamin A supplementation during pregnancy for maternal and newborn outcomes.

Overall, when trial results are pooled, vitamin A supplementation does not affect the risk of maternal mortality or perinatal mortality, and there is evidence that vitamin A supplements may reduce maternal clinical infection.

Fat-soluble vitamins A and E and health disparities in a cohort of pregnant women at delivery

Evaluating intakes and serum levels of vitamin A, vitamin E, and related compounds in a cohort of maternal–infant pairs in the Midwestern USA in relation to measures of health disparities found diet quality may be a public health concern in economically disadvantaged populations of industrialised societies leading to nutritional disadvantages as well.

Dietary vitamin A intake below the recommended daily intake during pregnancy and the risk of congenital diaphragmatic hernia in the offspring.

In normal-weight mothers, dietary vitamin A intake during pregnancy below the recommended daily intake is significantly associated with an increased risk of a child with CDH, which supports the retinoid hypothesis in human CDH.

Vitamin A in pediatrics: An update from the Nutrition Committee of the French Society of Pediatrics.

Vitamin A Requirements in Pregnancy and Lactation

ABSTRACT Pregnancy and lactation are critical life stages with unique nutritional requirements, including for vitamin A (VA). Current DRIs for VA were published in 2001. The objective of this review



Newborn Vitamin A Supplementation Reduced Infant Mortality in Rural Bangladesh

Newborn vitamin A dosing improved infant survival through the first 6 months of life in Bangladesh and corroborate previous findings from studies in Indonesia and India and provide additional evidence that vitamin A supplementation shortly after birth can reduce infant mortality in South Asia.

Maternal low-dose vitamin A or beta-carotene supplementation has no effect on fetal loss and early infant mortality: a randomized cluster trial in Nepal.

Small weekly doses of vitamin A or beta-carotene given to women before conception, during pregnancy, and through 24 wk postpartum did not improve fetal or early infant survival in Nepal.

Role of vitamin A in lung development.

  • R. Zachman
  • Medicine, Biology
    The Journal of nutrition
  • 1995
There is good rationale for presuming a role for vitamin A in lung development. In situ studies have demonstrated that certain retinoic acid (RA) receptor proteins are localized in a specific fashion

Postnatal distribution of vitamin A in liver, lung, heart and brain of the rat in relation to maternal vitamin A status.

The vitamin A contents of fetal hepatic and extra-hepatic tissues were increased with the age of pups and this increase was observed to be dependent on the supply of vitamin A to the mother.

Vitamin A Deficiency

This chapter describes the chemical structure of Vitamin A and its precursors, dietary sources, absorption, metabolism and functions, followed by discussions on the epidemiology of vitamin A deficiency, and its role in morbidity and mortality.

The role of vitamin A in mammalian reproduction and embryonic development.

Evidence strongly supports that in situ-generated all-trans retinoic acid (atRA) is the functional form of vitamin A in female reproduction and embryonic development, and the ability to reverse most reproductive and developmental blocks found in vitamin A deficiency with atRA is supported.

Vitamin A Deficiency: Health, Survival, and Vision

This book on vitamin A deficiency not only addresses ocular manifestations but also the broader context of child health and survival as well as mechanisms of vitamin A and the relationship of xerophthalmia to vitamin A status.

Vitamin A deficiency