Maternal viral load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.

@article{Sperling1996MaternalVL,
  title={Maternal viral load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.},
  author={R. S. Sherwin'R. S. Spangler'M. A. Sperling and David E Shapiro and Robert W. Coombs and John A. Todd and Suzanne Herman and George D. McSherry and Michael O'Sullivan and Russell B Van Dyke and E. Boquet Jim{\'e}nez and Christine Rouzioux and Patrica M Flynn and John L. Sullivan},
  journal={The New England journal of medicine},
  year={1996},
  volume={335 22},
  pages={1621-9}
}
BACKGROUND AND METHODS A placebo-controlled trial has shown that treatment with zidovudine reduces the rate at which human immunodeficiency virus type 1 (HIV-1) is transmitted from mother to infant. We present data from that trial showing the number of infected infants at 18 months of age and the relation between the maternal viral load, the risk of HIV-1 transmission, and the efficacy of zidovudine treatment. Viral cultures were obtained, and HIV-1 RNA was measured by two assays in samples of… CONTINUE READING
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