Maternal undernutrition results in altered renal pro-inflammatory gene expression concomitant with hypertension in adult male offspring that is ameliorated following pre-weaning growth hormone treatment

@article{Zhang2018MaternalUR,
  title={Maternal undernutrition results in altered renal pro-inflammatory gene expression concomitant with hypertension in adult male offspring that is ameliorated following pre-weaning growth hormone treatment},
  author={X. D. Zhang and C. Reynolds and C. Gray and M. Li and M. Vickers},
  journal={Journal of Developmental Origins of Health and Disease},
  year={2018},
  volume={10},
  pages={459 - 468}
}
Abstract An adverse early life environment is associated with increased cardiovascular disease in offspring. Work in animal models has shown that maternal undernutrition (UN) during pregnancy leads to hypertension in adult offspring, with effects thought to be mediated in part via altered renal function. We have previously shown that growth hormone (GH) treatment of UN offspring during the pre-weaning period can prevent the later development of cardiometabolic disorders. However, the… Expand
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