Maternal transmission of asthma risk.

  title={Maternal transmission of asthma risk.},
  author={Robert Lim and Lester Kobzik},
  journal={American journal of reproductive immunology},
  volume={61 1},
Maternal asthma significantly increases the risk of asthma in offspring, but the mechanisms remain poorly defined. We review animal models used to study the maternal effect, focusing on a murine model developed in our laboratory. Mother mice rendered allergic to ovalbumin produce offspring that are more susceptible to allergic sensitization, seen as airway hyperresponsiveness and allergic airway inflammation after a sensitization protocol, which has minimal effects on newborns from normal… CONTINUE READING
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