Maternal thyroid hormone deficiency affects the fetal neocorticogenesis by reducing the proliferating pool, rate of neurogenesis and indirect neurogenesis.

@article{Mohan2012MaternalTH,
  title={Maternal thyroid hormone deficiency affects the fetal neocorticogenesis by reducing the proliferating pool, rate of neurogenesis and indirect neurogenesis.},
  author={Vishwa Mohan and Rohit Sinha and Amrita Pathak and Leena Rastogi and Praveen Kumar and Amit Pal and Madan Madhav Godbole},
  journal={Experimental neurology},
  year={2012},
  volume={237 2},
  pages={477-88}
}
Neuronal progenitor cell proliferation and their optimum number are indispensable for neurogenesis, which is determined by cell cycle length and cell cycle quitting rate of the dividing progenitors. These processes are tightly orchestrated by transcription factors like Tbr2, Pax6, and E2f-1. Radial glia and intermediate progenitor cells (IPC) through direct and indirect neurogenesis maintain surface area and neocortical thickness during development. Here we show that fetal neurogenesis is… CONTINUE READING
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