Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child.

@article{Haddow1999MaternalTD,
  title={Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child.},
  author={J. Haddow and G. Palomaki and W. Allan and J. Williams and G. Knight and J. Gagnon and C. E. O’heir and M. Mitchell and R. Hermos and S. Waisbren and J. Faix and R. Klein},
  journal={The New England journal of medicine},
  year={1999},
  volume={341 8},
  pages={
          549-55
        }
}
BACKGROUND When thyroid deficiency occurs simultaneously in a pregnant woman and her fetus, the child's neuropsychological development is adversely affected. Whether developmental problems occur when only the mother has hypothyroidism during pregnancy is not known. METHODS In 1996 and 1997, we measured thyrotropin in stored serum samples collected from 25,216 pregnant women between January 1987 and March 1990. We then located 47 women with serum thyrotropin concentrations at or above the 99… Expand
MATERNAL THYROID DEFICIENCY DURING PREGNANCY AND SUBSEQUENT NEUROPSYCHOLOGICAL DEVELOPMENT OF THE CHILD
A BSTRACT Background When thyroid deficiency occurs simultaneously in a pregnant woman and her fetus, the child’s neuropsychological development is adversely affected. Whether developmental problemsExpand
Maternal Thyroid Deficiency During Pregnancy and Subsequent Neuropsychological Development of the Child
TLDR
It may be worthwhile to routinely screen for hypothyroidism in early pregnancy and testing at the first prenatal visit and prompt follow-up of those with positive results would permit timely treatment and could prevent adverse neuropsychological effects during early child development. Expand
Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child.
TLDR
From 1987 to the late 1990s, James Haddow and his team of researchers at the Foundation for Blood Research in Scarborough, Maine, studied children born to women who had thyroid deficiencies while pregnant with those children and proposed that undetected low thyroid hormone production in mothers could adversely affect the neuropsychological development of children. Expand
"Maternal Thyroid Deficiency During Pregnancy and Subsequent Neuropsychological Development of the Child" (1999), by James E. Haddow et al.
From 1987 to the late 1990s, James Haddow and his team of researchers at the Foundation for Blood Research in Scarborough, Maine, studied children born to women who had thyroid deficiencies whileExpand
Normal intellectual development in children born from women with hypothyroxinemia during their pregnancy.
  • G. Grau, A. Aguayo, +7 authors I. Rica
  • Medicine
  • Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements
  • 2015
TLDR
Assessing the relationship between thyroxin levels, in pregnant women with no thyroid disease and the intellectual development of their offspring in a non-iodine-deficient area found no association between the levels of maternal FT4 during pregnancy and the subsequent intellectual development the offspring from these pregnancies. Expand
Thyroxine Levels During Pregnancy in Healthy Women and Early Child Neurodevelopment
TLDR
Low free thyroxine levels in healthy pregnant women are related to a moderate delay in child neurodevelopment, similar in magnitude to that observed in mothers with untreated prepregnancy thyroid disorder. Expand
Maternal thyroid autoantibodies during the third trimester and hearing deficits in children: an epidemiologic assessment.
TLDR
Ant antenatal exposure to maternal TPOaAb during the third trimester of pregnancy is associated with impaired auditory development, and the direction and magnitude of the association were similar when an alternative case definition of SNHL was used. Expand
Maternal Thyroid Function During Pregnancy and the Child’s Linguistic and Sensory Development in the Northern Finland Birth Cohort 1986
TLDR
There was no association between maternal thyroid dysfunction during pregnancy and sensory and linguistic development impairment in childhood and a somewhat higher prevalence of vision impairment was seen in children of hypothyroid and hypothyroxinemic mothers, which merits further research. Expand
Thyroid diseases in pregnancy
  • R. Gärtner
  • Medicine
  • Current opinion in obstetrics & gynecology
  • 2009
TLDR
The recommended dose for iodine intake during pregnancy had been increased from 200 to 250 μg/day, because recent studies revealed that even mild-to-moderate iodine intake might affect the neuropsychological development of the child. Expand
Thyroid function and intellectual development of children of mothers taking methimazole during pregnancy
TLDR
No deleterious effect occurred in thyroid function and physical and intellectual development of children whose mothers were treated during pregnancy with doses of MMI up to 20 mg daily. Expand
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MATERNAL THYROID DEFICIENCY DURING PREGNANCY AND SUBSEQUENT NEUROPSYCHOLOGICAL DEVELOPMENT OF THE CHILD
A BSTRACT Background When thyroid deficiency occurs simultaneously in a pregnant woman and her fetus, the child’s neuropsychological development is adversely affected. Whether developmental problemsExpand
SUBCLINICAL HYPOTHYROIDISM DURING PREGNANCY : POSITION STATEMENT FROM THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS
The importance of thyroid hormones for normal fetal development is well established. Through animal experiments (1,2) and clinical studies (3,4), thyroid hormones have been clearly found to beExpand
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TLDR
The results suggest that maternal autoimmune thyroid disease is associated with much higher prevalence of transient congenital hypothyroidism than suspected, and recommend thyroid assessment of such women, if this information is not available. Expand
MATERNAL THYROID HORMONE LEVELS IN PREGNANCY AND THE SUBSEQUENT COGNITIVE AND MOTOR PERFORMANCE OF THE CHILDREN
TLDR
Serum levels of thyroxine and triiodothyronine during pregnancy were measured in women from a severely iodine deficient region in the highlands of Papua New Guinea and measures made of intellectual ability and motor competence were examined. Expand
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TLDR
The spectrum of neonatal thyroid disease is expanded and it is suggested that differing disease syndromes in the newborn can occur depending on whether stimulating or blocking antibodies predominate in the mother. Expand
Thyroid function in human pregnancy. V. Incidence of maternal serum low butanol-extractable iodines and of normal gestational TBG and TBPA capacities; retardation of 8-month-old infants.
Abstract Although irreversible damage to the fetal central nervous system has been attributed to intrauterine thyroid deficiency, the incidence, in uncomplicated human pregnancies, of low maternalExpand
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TLDR
It is suggested that maternal thyroid function during pregnancy might be an important factor in the prognosis of infants born to mothers with chronic thyroiditis. Expand
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TLDR
This data indicates that serum levels of unconjugated estriol and chorionic gonadotropin, which are abnormally low and abnormally high, respectively, in women carrying fetuses affected by Down's syndrome can be detected by measuring maternal serum alpha-fetoprotein during the second trimester in the general population of pregnant women. Expand
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TLDR
The results indicate that the need for thyroxine increases in many women with primary hypothyroidism when they are pregnant, as reflected by an increase in serum thyrotropin concentrations. Expand
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TLDR
The laboratory and clinical data are compatible with the blocking nature of TBII, resulting in transient newborn hypothyroidism and an athyreotic appearance on scan. Expand
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