Maternal syphilis and vertical perinatal transmission of human immunodeficiency virus type‐1 infection

@article{Lee1998MaternalSA,
  title={Maternal syphilis and vertical perinatal transmission of human immunodeficiency virus type‐1 infection},
  author={M. J. Lee and Rebecca Hallmark and Lisa M Frenkel and Giuseppe del Priore},
  journal={International Journal of Gynecology \& Obstetrics},
  year={1998},
  volume={63}
}
Objectives: To identify risk factors for vertical HIV transmission that may provide opportunities for the prevention of future pediatric HIV infection. Study Design: A prospective cohort of 44 pregnant HIV(+) women and their 53 offspring was followed between July 1989 and July 1996. Results: Secondary and latent maternal syphilis infection was diagnosed in four pregnancies with VDRL titers ≥ 1:128. Concurrent maternal syphilis infection was associated with 100% vertical HIV transmission (4/4… Expand
Maternal syphilis infection is associated with increased risk of mother-to-child transmission of HIV in Malawi
TLDR
Maternal syphilis is associated with IU and IP/PP HIV MTCT, and screening and early treatment of maternal syphilis during pregnancy may reduce pediatric HIV infections. Expand
Syphilis in HIV-infected Mothers and Infants: Results from the NICHD/HPTN 040 Study
TLDR
Syphilis continues to be a common co-infection in HIV-infected women and can facilitate in utero transmission of HIV to infants, especially in low- and middle-income countries where both diseases are common. Expand
Correlates of Syphilis Seroreactivity Among Pregnant Women: The HIVNET 024 Trial in Malawi, Tanzania, and Zambia
TLDR
Many women without identified risk factors were syphilis-seropositive, and younger HIV-infected women were at highest risk, suggesting universal integrated antenatal HIV and syphilis screening and treatment is essential in sub-Saharan African settings. Expand
Prevention of Mother-to-Child Transmission of HIV and Syphilis
TLDR
The rates, burden, and consequences of mother-to-child transmission of HIV and syphilis; the effectiveness of interventions to decrease transmission; the estimated cost-effectiveness of these interventions; and several successful PMTCT programmatic approaches are reviewed. Expand
Syphilis Among HIV-Infected Mothers and Their Infants in Texas From 1988 to 1994
TLDR
The congenital syphilis rate among Texas infants born to HIV-infected mothers was almost 50 times that of the general population. Expand
Severe, rapidly progressive human immunodeficiency virus type 1 disease in newborns with coinfections
TLDR
A distinct group of HIV-1-infected babies may clinically manifest in the neonatal period with perinatal coinfections, subsequent rapidly progressive HIV- 1 and early death. Expand
Prevention of perinatal HIV transmission during pregnancy.
TLDR
Major prospective and retrospective antiretroviral treatment studies in HIV-infected pregnant women are summarized and the impact of recent advances in the management of HIV infection in pregnancy is discussed. Expand
Reviews Prevention of perinatal HIV transmission during pregnancy
TLDR
Major prospective and retrospective antiretroviral treatment studies in HIV-infected pregnant women are summarized and the impact of recent advances in the management of HIV infection in pregnancy is discussed. Expand
Transmission of HIV-1 from mother to infant.
  • W. Andiman
  • Medicine
  • Current opinion in pediatrics
  • 2002
In the developed world, antiretroviral therapy (ART) administered to the mother during pregnancy and intrapartum and to the infant in the neonatal period has resulted in a reduction of the overallExpand
Maternal HIV infection and preterm delivery outcomes at an urban district hospital in KwaZulu-Natal 2011
TLDR
The aim of this study was to explore the relationship between preterm delivery and maternal HIV infections at an urban district hospital in KwaZulu-Natal in 2011 and determine the associations and outcomes of preterm deliveries at a high patient load urbanDistrict hospital. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 35 REFERENCES
Risk for perinatal HIV-1 transmission according to maternal immunologic, virologic, and placental factors.
TLDR
Identifiable subgroups of HIV-1-infected women based on maternal and placental characteristics had between a 7% and 71% risk of perinatal HIV- 1 transmission, and not only the overall rate of transmission but the impact of different risk factors for transmission appear to vary over the course of HIV infection. Expand
A prospective study of infants born to women seropositive for human immunodeficiency virus type 1
TLDR
It is concluded that approximately one third of the infants born to seropositive mothers will have evidence of HIV-1 infection or of AIDS by the age of 18 months, and that about one fifth of this group will have died. Expand
A prospective study of infants born to women seropositive for human immunodeficiency virus type 1.
TLDR
It is concluded that approximately one third of the infants born to seropositive mothers will have evidence of HIV-1 infection or of AIDS by the age of 18 months, and that about one fifth of this group will have died. Expand
Rapid increase of both HIV‐1 infection and syphilis among pregnant women in Nairobi, Kenya
TLDR
Data confirm an association between HIV-1 and syphilis infection, and indicate that both are spreading rapidly among women in Nairobi outside high-risk groups, and increased efforts to control both infections are urgently required. Expand
Postnatal transmission of human immunodeficiency virus type 1 from mother to infant.
TLDR
A prospective cohort study in Kigali, Rwanda, of 212 mother—infant pairs who were seronegative for HIV-1 at delivery and after a mean follow-up of 16.6 months, 16 of the 212 mothers became seropositive for HIV in their infants, and one infant was excluded from the analysis because of a positive test on the blood sample obtained at birth. Expand
Transmission of HIV-1 infections from mothers to infants in Haiti. Impact on childhood mortality and malnutrition. The CDS/JHU AIDS Project Team.
TLDR
Of 4588 pregnant women in a high-risk Haitian population, 443 were serologically positive for the human immunodeficiency virus type 1 (HIV-1), and mothers-to-infant HIV-1 transmission rate in these breast-fed infants was 25%, similar to the rates reported for non-breast-fed populations in the United States and Europe. Expand
The use of viral culture and p24 antigen testing to diagnose human immunodeficiency virus infection in neonates
TLDR
The fact that this usually sensitive technique fails to identify about half the ultimately infected neonates suggests that vertical transmission of HIV may occur late in pregnancy or during delivery. Expand
The use of viral culture and p24 antigen testing to diagnose human immunodeficiency virus infection in neonates
TLDR
The fact that this usually sensitive technique fails to identify about half the ultimately infected neonates suggests that vertical transmission of HIV may occur late in pregnancy or during delivery. Expand
Multiple Blood‐borne and Sexually Transmitted Infections in Sexually Transmitted Disease Clinic and Hospital Emergency Room Patient Populations
TLDR
It is suggested that HIV-1 and/or HTLV-I/II infected individuals in STD clinic and emergency rooms are highly likely to have had past infections with HBV or HCV. Expand
Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.
TLDR
In pregnant women with mildly symptomatic HIV disease and no prior treatment with antiretroviral drugs during the pregnancy, a regimen consisting of zidovudine given ante partum and intra partum to the mother and to the newborn for six weeks reduced the risk of maternal-infant HIV transmission by approximately two thirds. Expand
...
1
2
3
4
...