Maternal social separation of adolescent rats induces hyperactivity and anxiolytic behavior.

@article{Kwak2009MaternalSS,
  title={Maternal social separation of adolescent rats induces hyperactivity and anxiolytic behavior.},
  author={Hyong Ryol Kwak and Jae Jae Won Won Lee Lee and Kwang-Jun Kwon and Chang Don Kang and Il Young Cheong and W. C. Chun and Sung-Soo Kim and Hee Jae Lee},
  journal={The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology},
  year={2009},
  volume={13 2},
  pages={79-83}
}
Exposure to early stressful adverse life events such as maternal and social separation plays an essential role in the development of the nervous system. Adolescent Sprague-Dawley rats that were separated on postnatal day 14 from their dam and litters (maternal social separation, MSS) showed hyperactivity and anxiolytic behavior in the open field test, elevated plus-maze test, and forced-swim test. Biologically, the number of astrocytes was significantly increased in the prefrontal cortex of MSS… CONTINUE READING

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