Maternal smoking and fetal sex significantly affect metabolic enzyme expression in the human fetal liver.

@article{OShaughnessy2011MaternalSA,
  title={Maternal smoking and fetal sex significantly affect metabolic enzyme expression in the human fetal liver.},
  author={Peter O'Shaughnessy and Ana Cec{\'i}lia Ferreira Monteiro and Siladitya Bhattacharya and Paul A Fowler},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2011},
  volume={96 9},
  pages={
          2851-60
        }
}
CONTEXT Pollutants and toxicants passing from the mother to the fetus may damage developing organ systems. The human fetal liver is both a potential target organ and a critical defense against exposure to such xenochemicals. OBJECTIVE The aim of the study was to determine the effects of human fetal toxicant exposure, via maternal smoking, on metabolic enzyme transcripts in the fetal liver. DESIGN AND SETTING We conducted an observational study of mRNA transcripts and proteins in livers from… CONTINUE READING
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