Maternal serum proteome changes between the first and third trimester of pregnancy in rural southern Nepal.

@article{Scholl2012MaternalSP,
  title={Maternal serum proteome changes between the first and third trimester of pregnancy in rural southern Nepal.},
  author={Peter F. Scholl and Robert N Cole and Ingo Ruczinski and Marjan Gucek and Roberto D{\'i}ez and Alison Rennie and Christopher K Nathasingh and Kathrin Schulze and Parul Christian and James D. Yager and John D. Groopman and Keith P West},
  journal={Placenta},
  year={2012},
  volume={33 5},
  pages={424-32}
}
Characterization of normal changes in the serum proteome during pregnancy may enhance understanding of maternal physiology and lead to the development of new gestational biomarkers. In 23 Nepalese pregnant women who delivered at term, two-dimensional difference in-gel electrophoresis (DIGE) was used to assess changes in relative protein abundance between paired serum samples collected in the first and third trimesters. One-hundred and forty-five of over 700 protein spots in DIGE gels (pI 4.2-6… CONTINUE READING