Maternal serum alpha-fetoprotein monitoring. Council on Scientific affairs.

  • Published 1982 in JAMA


Proposed Food and Drug Administration regulations for alpha-fetoprotein (AFP) testing to detect fetal neural tube defects, and an American College of Obstetricians and Gynecologists-American Academy of Pediatrics Task Force report on the subject, are discussed. Information is provided on the predictive value of AFP testing for detecting fetal abnormality and the need for a multistage testing procedure. The use of sonography and amniocentesis when AFP levels are abnormally high, and the risks to mothers and fetuses, are described. Recommendations are made regarding mass screening, the need for additional research, and the use of the testing in high risk patients.

Cite this paper

@article{1982MaternalSA, title={Maternal serum alpha-fetoprotein monitoring. Council on Scientific affairs.}, author={}, journal={JAMA}, year={1982}, volume={247 10}, pages={1478-81} }