Maternal separation exacerbates Alzheimer's disease-like behavioral and pathological changes in adult APPswe/PS1dE9 mice.

@article{Hui2017MaternalSE,
  title={Maternal separation exacerbates Alzheimer's disease-like behavioral and pathological changes in adult APPswe/PS1dE9 mice.},
  author={Jianjun Hui and Gai-feng Feng and Caifeng Zheng and Hui Jin and Ning Jia},
  journal={Behavioural brain research},
  year={2017},
  volume={318},
  pages={18-23}
}
Alzheimer's disease (AD), the most common neurodegenerative disorder that gradually destroys memory and cognitive abilities in the elderly, makes a huge emotional and economic burden on the patients and their families. The presence of senile plaques and the loss of cholinergic neurons in the brain are two neuropathological hallmarks of AD. Maternal separation (MS) is an animal paradigm designed to make early life stress. Studies on wild type rodents showed that MS could induce AD-like cognitive… CONTINUE READING