Maternal separation altered behavior and neuronal spine density without influencing amphetamine sensitization.

@article{Muhammad2011MaternalSA,
  title={Maternal separation altered behavior and neuronal spine density without influencing amphetamine sensitization.},
  author={Arif Muhammad and Bryan Kolb},
  journal={Behavioural brain research},
  year={2011},
  volume={223 1},
  pages={7-16}
}
We studied the long-term influence of maternal separation (MS) on periadolescent behavior, adult amphetamine (AMPH) sensitization, and structural plasticity in the corticolimbic regions in rats. Male and female pups, separated daily for 3h from the dam during postnatal day 3-21, were tested for periadolescent exploratory, emotional, cognitive, and social behaviors. The development and persistence of drug-induced behavioral sensitization were tested by repeated AMPH administration and a… CONTINUE READING

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