Maternal separation affects cocaine-induced locomotion and response to novelty in adolescent, but not in adult rats.

@article{Marin2004MaternalSA,
  title={Maternal separation affects cocaine-induced locomotion and response to novelty in adolescent, but not in adult rats.},
  author={Marcelo Tadeu Marin and Cle{\'o}patra da Silva Planeta},
  journal={Brain research},
  year={2004},
  volume={1013 1},
  pages={83-90}
}
Maternal separation is known to exert long-term effects on both behavior and the neuroendocrine system. We investigated cocaine-induced locomotor activation as well as the locomotor and corticosterone response to forced novelty in maternally separated adolescent and adult rats. Maternal separation consisted of separating litters from their dams daily during 5 h from postnatal days 2 to 6. Control animals were subjected only to regular cage changes. Cocaine- (10 mg/kg, i.p.) and novelty-induced… CONTINUE READING

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