Maternal rescue of transforming growth factor-beta 1 null mice.

@article{Letterio1994MaternalRO,
  title={Maternal rescue of transforming growth factor-beta 1 null mice.},
  author={John James Letterio and Andrew G. Geiser and Ashok B. Kulkarni and Nanette S. Roche and Michael B. Sporn and Anjeanette Roberts},
  journal={Science},
  year={1994},
  volume={264 5167},
  pages={
          1936-8
        }
}
Maternal sources of transforming growth factor-beta 1 (TGF-beta 1) are shown here to contribute to the normal appearance and perinatal survival of TGF-beta 1 null newborn mice. Labeled TGF-beta 1 crossed the placenta and was recovered intact from various tissues after oral administration to mouse pups. TGF beta-1 protein was also detected in cells recovered from breast milk. In immunohistochemical analyses, TGF-beta 1 null embryos and null newborn pups born to TGF-beta 1 heterozygotes stained… CONTINUE READING
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