Maternal regulation of embryonic growth: the role of vasoactive intestinal peptide.

  title={Maternal regulation of embryonic growth: the role of vasoactive intestinal peptide.},
  author={Catherine Y. Spong and Sung Joong Lee and S K Mccune and Gretchen Gibney and Daniel T Abebe and Ruben J Alvero and Douglas E. Brenneman and Joanna M. Hill},
  volume={140 2},
Vasoactive intestinal peptide (VIP) is an important growth regulator of the embryonic day (E)9-E11 mouse. In comparably aged rat embryos, VIP messenger RNA (mRNA) is not detectable; however, peak concentrations of VIP in maternal rat serum indicate a nonembryonic source. In the current study, mouse maternal and embryonic tissues were examined from E6-E12. Although RT-PCR revealed VIP mRNA in E6-E7 conceptuses, by E8 (when extraembryonic tissues could be separated from the embryo), VIP mRNA was… CONTINUE READING


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