Maternal pregravid weight is the primary determinant of serum leptin and its metabolic associations in pregnancy, irrespective of gestational glucose tolerance status.

@article{MapleBrown2012MaternalPW,
  title={Maternal pregravid weight is the primary determinant of serum leptin and its metabolic associations in pregnancy, irrespective of gestational glucose tolerance status.},
  author={Louise J. Maple-Brown and Chang Ye and Anthony J. G. Hanley and Philip W. Connelly and Mathew Sermer and Bernard Zinman and Ravi Retnakaran},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2012},
  volume={97 11},
  pages={4148-55}
}
CONTEXT Several previous studies have investigated circulating levels of the adipokine leptin in relation to gestational diabetes mellitus (GDM). However, these studies have yielded markedly conflicting results, including increased, decreased, and unchanged leptin levels in women with GDM as compared with their peers. OBJECTIVE We sought to evaluate the metabolic determinants of serum leptin in a well-characterized cohort reflecting the full spectrum of glucose intolerance in pregnancy… CONTINUE READING