Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of Parents and Children

@inproceedings{Sharp2015MaternalPB,
  title={Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of Parents and Children},
  author={Gemma C Sharp and Debbie A Lawlor and Rebecca C Richmond and Abigail Fraser and Andrew J Simpkin and Matthew J. Suderman and Hashem A. Shihab and Oliver Lyttleton and Wendy L. Mcardle and Susan M. Ring and Tom R. Gaunt and George Davey Smith and Caroline Relton},
  booktitle={International journal of epidemiology},
  year={2015}
}
BACKGROUND Evidence suggests that in utero exposure to undernutrition and overnutrition might affect adiposity in later life. Epigenetic modification is suggested as a plausible mediating mechanism. METHODS We used multivariable linear regression and a negative control design to examine offspring epigenome-wide DNA methylation in relation to maternal and offspring adiposity in 1018 participants. RESULTS Compared with neonatal offspring of normal weight mothers, 28 and 1621 CpG sites were… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 30 times over the past 90 days. VIEW TWEETS
44 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 44 extracted citations

Similar Papers

Loading similar papers…