Maternal passive smoking during pregnancy and neural tube defects in offspring: a meta-analysis

  title={Maternal passive smoking during pregnancy and neural tube defects in offspring: a meta-analysis},
  author={Meng Wang and Zhi-Ping Wang and Meng Zhang and Zhong-tang Zhao},
  journal={Archives of Gynecology and Obstetrics},
AbstractPurposeThis study aims to examine the association between maternal passive smoking during pregnancy and the occurrence of neural tube defects (NTDs) in offspring.Methods We retrieved studies published on the association between maternal passive smoking during pregnancy and the occurrence of NTDs in offspring. Meta-analysis was applied to calculate the pooled effect estimates and their 95 % confidence intervals (CIs) using data from 10 case–control studies. The publication bias was… 

Nausea and Vomiting in Early Pregnancy and the Risk of Neural Tube Defects: a Case-Control Study

It is concluded that severe/moderate NVP has an association with the risk of NTDs, which was not found in the group with intake of folic acid supplements, which should be recommended to use for the prevention of N TDs.

Association between maternal smoking history and congenital anomalies in children: Results from the Japan Environment and Children's Study

The results indicate that continuing to smoke during pregnancy is associated with increased risk of trisomy and any congenital anomalies in the general Japanese population.

Congenital malformations are associated with secondhand smoke among nonsmoking women: A meta-analysis.

Findings highlight the necessity of improving community awareness to prevent secondhand smoke exposure during the preconception and conception periods and increase the risk for overall and several organ-system malformations.

Parental smoking during pregnancy: findings from the Growing Up in New Zealand cohort.

There are differences in a range of contextual and behavioural factors related to smoking before and during pregnancy, including low educational achievement, being young, Māori and multiparous were all associated with smoking during pregnancy.

Health outcomes of smoking during pregnancy and the postpartum period: an umbrella review

This umbrella review provides a comprehensive analysis of the overall health impacts of SDP and shows that maternal SDP is not only associated with short-term health conditions but also some which can have life-long detrimental impacts (e.g. obesity, intellectual impairment).

Association of paternal smoking with the risk of neural tube defects in offspring: A systematic review and meta‐analysis of observational studies

The present study aimed at providing some epidemiological evidences to assess the association of paternal smoking with the risk of neural tube defects (NTDs) and its specific subtypes in offspring,

Risk factors associated with neural tube defects in infants referred to western Iranian obstetrical centers; 2013–2014

Before fertilization and during pregnancy, mothers should be examined in terms of exposure to harmful agents, diet, and nutritional status in order to identify possible risk factors and find opportunities to prevent NTDs in infants.

Meta‐analysis of the association of maternal smoking and passive smoking during pregnancy with neural tube defects

  • Xin MengYanxin SunWenhou DuanC. Jia
  • Medicine, Psychology
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2018
It is unclear whether the incidence of neural tube defects (NTDs) is greater with maternal smoking or with passive smoking during pregnancy, but research suggests maternal smoking is associated with higher incidence of NTDs.



[Maternal passive smoking and the risk of neural tube defects: a case-control study in Shanxi province, China].

Maternal passive smoking during peri-conceptional period increased the risk of NTDs in offspring, and there was a marked dose-response relation between maternal passive smoking and the risk Of neural tube defects in offspring.

Parental recreational drug use and risk for neural tube defects.

Periconceptional maternal use of recreational drugs increased the risk of having neural tube defect (NTD)-affected pregnancies but decreased risks observed for these maternal exposures were due to reporting bias, a disproportionate number of drug-exposed NTD cases among spontaneous abortuses that could not be ascertained, or some other bias.

A population-based case-control study of risk factors for neural tube defects in Shenyang, China

A history of previous birth defect-affected pregnancy, a history of maternal fever or cold, use of analgesics, antipyretics, and oral contraceptives, exposure to passive smoking, folic acid use, and consumption of fresh vegetable and fruit may be associated with NTD risk.

Maternal smoking, passive tobacco smoke, and neural tube defects.

Results suggest that maternal exposure to passive smoke is associated with NTDs, and women who plan on becoming pregnant should minimize their exposure to Passive smoke and refrain from smoking.

Mid-pregnancy cotinine and risks of orofacial clefts and neural tube defects.

Partner cigarette smoking and risk of neural tube defects among infants of non-smoking women in northern China

Peri-conceptional exposure to partner smoking may increase the risk of NTDs in the offspring of Chinese non-smoking women.

Maternal Exposures to Cigarette Smoke, Alcohol, and Street Drugs and Neural Tube Defect Occurrence in Offspring

This study suggests that cigarette smoke including secondhand exposure is not only hazardous to the mother but may also interfere with neural tube closure in the developing embryo.

Maternal smoking and congenital malformations: an epidemiological study.

It was found that women who reported smoking more than 20 cigarettes a day during pregnancy had a relative risk of about 1.6 for congenital malformations in the offspring of that pregnancy compared with women who said they had not smoked at all during pregnancy.

A population-based case-control study of risk factors for neural tube defects in four high-prevalence areas of Shanxi province, China.

Most of the environmental factors had stronger positive and negative associations with risk for anencephaly rather than spina bifida, whereas history of a previous birth defect-associated pregnancy, as well as legume consumption, were more strongly associated with the risk for spina Bifida than for anencesphaly.

Maternal smoking habits and congenital malformations: a population study.

It is suggested that maternal smoking does not have teratogenic effects in the offspring, except in the case of neural tube defects, where the effect is at most modest.