Maternal obesity eliminates the neonatal lamb plasma leptin peak.

  title={Maternal obesity eliminates the neonatal lamb plasma leptin peak.},
  author={N M Long and Stephen P. Ford and Peter W Nathanielsz},
  journal={The Journal of physiology},
  volume={589 Pt 6},
A neonatal peak in rodent plasma leptin plays a central role in regulating development of the hypothalamic appetite control centres. Maternal obesity lengthens and amplifies the peak in altricial rodent species. The precise timing and characteristics of the neonatal leptin peak have not been established in offspring of either normal or obese mothers in any precocial species. We induced obesity by feeding female sheep for 60 days before conception, and throughout pregnancy and parturition with… CONTINUE READING
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