Maternal obesity alters endoplasmic reticulum homeostasis in offspring pancreas

  title={Maternal obesity alters endoplasmic reticulum homeostasis in offspring pancreas},
  author={Jumpei Soeda and Angelina Mouralidarane and Paul Cordero and Jiawei Li and Vi Nguyen and Rebeca M P Carter and Sabrina R. Kapur and J M Santos Pombo and Lucilla Poston and Paul D Taylor and Manlio Vinciguerra and Jude A Oben},
  booktitle={Journal of Physiology and Biochemistry},
The prevalence of non-alcoholic fatty pancreas disease (NAFPD) is increasing in parallel with obesity rates. Stress-related alterations in endoplasmic reticulum (ER), such as the unfolded protein response (UPR), are associated with obesity. The aim of this study was to investigate ER imbalance in the pancreas of a mice model of adult and perinatal diet-induced obesity. Twenty female C57BL/6J mice were assigned to control (Con) or obesogenic (Ob) diets prior to and during pregnancy and lactation… CONTINUE READING
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