Maternal nicotine exposure increases oxidative stress in the offspring.

  title={Maternal nicotine exposure increases oxidative stress in the offspring.},
  author={Jennifer E. Bruin and Maria A. Petre and Megan A Lehman and Sandeep Raha and Hertzel C. Gerstein and Katherine M Morrison and Alison C Holloway},
  journal={Free radical biology & medicine},
  volume={44 11},
Fetal and neonatal nicotine exposure causes beta-cell apoptosis and loss of beta-cell mass, but the underlying mechanisms are unknown. The goal of this study was to determine whether maternally derived nicotine can act via the pancreatic nicotinic acetylcholine receptor (nAChR) during fetal and neonatal development to induce oxidative stress in the pancreas. Female Wistar rats were given saline or nicotine (1 mg/kg/day) via subcutaneous injection for 2 weeks prior to mating until weaning… CONTINUE READING


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