Maternal intake of fat, riboflavin and nicotinamide and the risk of having offspring with congenital heart defects

  title={Maternal intake of fat, riboflavin and nicotinamide and the risk of having offspring with congenital heart defects},
  author={Huberdina P. M. Smedts and Maryam Rakhshandehroo and Anna C. Verkleij-Hagoort and Jeanne H. M. de Vries and Jaap J Ottenkamp and Eric A. P. Steegers and R{\'e}gine P. M. Steegers-Theunissen},
  journal={European Journal of Nutrition},
BackgroundWith the exception of studies on folic acid, little evidence is available concerning other nutrients in the pathogenesis of congenital heart defects (CHDs). Fatty acids play a central role in embryonic development, and the B-vitamins riboflavin and nicotinamide are co-enzymes in lipid metabolism.Aim of the studyTo investigate associations between the maternal dietary intake of fats, riboflavin and nicotinamide, and CHD risk in the offspring.MethodsA case-control family study was… 
Maternal folic acid supplementation and dietary folate intake and congenital heart defects
It is suggested that folic acid supplementation before pregnancy was associated with a reduced risk of CHDs, lower dietary folate intake during pregnancy wasassociated with increased risk.
Periconceptional nutrient intakes and risks of conotruncal heart defects.
Evidence continues to accumulate to show that nutrients, particularly folate, influence risks of structural birth defects, and associations were observed among women who did not use vitamin supplements periconceptionally.
A derangement of the maternal lipid profile is associated with an elevated risk of congenital heart disease in the offspring.
Maternal Dietary Fat Intake and the Risk of Congenital Heart Defects in Offspring
After adjusting for total energy intake, maternal periconceptional dietary fat intake has a modest association with risk of a few specific CHDs, and the question about whether maternal lipid metabolism, as opposed to fat intake, may influence cardiac development is raised.
Role of micronutrients in the periconceptional period.
Although human studies are scarce, and conclusive evidence is provided solely for periconceptional folate and prevention of neural tube defects (NTDs), the overall data indicate that micronutrients may affects fertility, embryogenesis and placentation, and the prophylactic use of some micronUTrients may be useful in preventing several adverse pregnancy outcomes.
Macronutrient and Micronutrient Intake during Pregnancy: An Overview of Recent Evidence
Newly published studies support the use of calcium supplementation to prevent hypertensive disorders of pregnancy, particularly in women at high risk or with low dietary calcium intake.
Disorders of riboflavin metabolism
This review focuses on the clinical and biochemical features associated with biallelic FLAD1 mutations leading to FAD synthase deficiency, the only known primary defect in flavocoenzyme synthesis, in addition to providing an overview of clinical disorders associated with nutritional deficiency of riboflavin and primary defects of rib oflavin transport.
Dietary Reference Values for riboflavin
The EFSA Panel on Dietetic Products, Nutrition and Allergies derives dietary reference values (DRVs) for riboflavin on the basis of the inflection point in the urinary rib oflavin excretion curve reported in four intervention studies and considers that erythrocyte glutathione reductase activation coefficient is a useful biomarker, but has limitations.
Poor thiamin and riboflavin status is common among women of childbearing age in rural and urban Cambodia.
Suboptimal status of both thiamin and riboflavin were common in Cambodian women, with substantially higher rates among women living in rural Prey Veng than in urban Phnom Penh, and the unexpected finding of high rib oflavin inadequacy status in Vancouver women warrants further investigation.


Dietary intake of B-vitamins in mothers born a child with a congenital heart defect
A diet low in vitamin B12 is associated with an increased risk of a child with a CHD, especially in low educated women, and may imply that the hyperhomocysteinemic mothers and their children should be targeted for nutritional interventions.
Maternal dietary B vitamin intake, other than folate, and the association with orofacial cleft in the offspring
The periconceptional intake of thiamine, niacin and pyridoxine was significantly lower in mothers of an OFC child, and seems to contribute to the prevention of OFC.
Low maternal dietary intakes of iron, magnesium, and niacin are associated with spina bifida in the offspring.
The nutritional intake of Dutch women from food groups containing iron and folate seems to be compromised, and low preconceptional intakes of plant proteins, iron, magnesium, and niacin are associated with a 2- to 5-fold increased risk of spina bifida.
Riboflavin (vitamin B-2) and health.
  • H. Powers
  • Medicine, Biology
    The American journal of clinical nutrition
  • 2003
There is reasonably good evidence that poor riboflavin status interferes with iron handling and contributes to the etiology of anemia when iron intakes are low, and discrepancies between dietary intake data and biochemical data suggest either that requirements are higher than hitherto thought or that biochemical thresholds for deficiency are inappropriate.
Maternal Nutrient Intakes and Risk of Orofacial Clefts
The finding of no reduction in clefting risk with periconceptional use of supplements containing folic acid is inconsistent with many previous observations but not all.
Maternal Western Dietary Patterns and the Risk of Developing a Cleft Lip With or Without a Cleft Palate
The use of the maternal Western diet increases the risk of offspring with a cleft lip or cleft palate approximately two fold, and dietary and lifestyle profiles should be included in preconception screening programs.
Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring.
Women who take multivitamins have 30-35% lower risk of delivering offspring with either conotruncal or limb defects, and among non-vitamin using women, consumption of cereal containing folic acid was also associated with reduced risk for both defects.
Validation of the assessment of folate and vitamin B12 intake in women of reproductive age: the method of triads
The adapted FFQ is a reliable tool to estimate the dietary intake of energy, macronutrients, folate and vitamin B12 in women of reproductive age and is suitable for the investigation of nutrient-disease associations in future.
Do multivitamin or folic acid supplements reduce the risk for congenital heart defects? Evidence and gaps
The evidence is reviewed and the evidence suggested is a framework for further investigation in this area, and the use of multivitamin supplements around the time of conception and during early pregnancy with a reduced risk for heart defects in the offspring is suggested.
Prepregnancy obesity as a risk factor for structural birth defects.
The results suggest a weak to moderate positive association of maternal obesity with 7 of 16 categories of birth defects and a strong inverse association with gastroschisis, which is related to undiagnosed diabetes.