Maternal intake of fat, riboflavin and nicotinamide and the risk of having offspring with congenital heart defects

  title={Maternal intake of fat, riboflavin and nicotinamide and the risk of having offspring with congenital heart defects},
  author={Huberdina P. M. Smedts and M. Rakhshandehroo and A. Verkleij-Hagoort and J. D. Vries and J. Ottenkamp and E. Steegers and R. Steegers-Theunissen},
  journal={European Journal of Nutrition},
  • Huberdina P. M. Smedts, M. Rakhshandehroo, +4 authors R. Steegers-Theunissen
  • Published 2008
  • Medicine, Biology
  • European Journal of Nutrition
  • BackgroundWith the exception of studies on folic acid, little evidence is available concerning other nutrients in the pathogenesis of congenital heart defects (CHDs). Fatty acids play a central role in embryonic development, and the B-vitamins riboflavin and nicotinamide are co-enzymes in lipid metabolism.Aim of the studyTo investigate associations between the maternal dietary intake of fats, riboflavin and nicotinamide, and CHD risk in the offspring.MethodsA case-control family study was… CONTINUE READING
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