Maternal insulin-like growth factor 1 and 2 differentially affect the renin-angiotensin system during pregnancy in the guinea pig.

@article{Standen2015MaternalIG,
  title={Maternal insulin-like growth factor 1 and 2 differentially affect the renin-angiotensin system during pregnancy in the guinea pig.},
  author={Prue Standen and Amanda N Sferruzzi-Perri and Robyn L Taylor and Gary K Heinemann and Jamie V Zhang and Amanda R. Highet and Kirsty G. Pringle and Julie A Owens and Vasumathy Kumarasamy and Eugenie R Lumbers and Claire T. Roberts},
  journal={Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society},
  year={2015},
  volume={25 3},
  pages={141-7}
}
OBJECTIVE Insulin-like growth factors (IGFs) are known to interact with the renin-angiotensin system (RAS). We previously demonstrated that administration of IGF1 to guinea pigs in early to mid pregnancy promotes placental function and fetal growth in mid to late gestation. Early administration of IGF2 had sustained, but not acute, effects on these… CONTINUE READING