Maternal induction of ventral fate by zebrafish radar.

@article{Sidi2003MaternalIO,
  title={Maternal induction of ventral fate by zebrafish radar.},
  author={Samuel Sidi and Carole Goutel and Nadine Peyri{\'e}ras and Fr{\'e}d{\'e}ric Marc Rosa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 6},
  pages={3315-20}
}
In vertebrate embryos, maternal determinants are thought to preestablish the dorsoventral axis by locally activating zygotic ventral- and dorsal-specifying genes, e.g., genes encoding bone morphogenetic proteins (BMPs) and BMP inhibitors, respectively. Whereas the canonical Wntbeta-catenin pathway fulfills this role dorsally, the existence of a reciprocal maternal ventralizing signal remains hypothetical. Maternal noncanonical WntCa(2+) signaling may promote ventral fates by suppressing Wntbeta… CONTINUE READING

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C. Chang, A. Hemmati-Brivanlou
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