Maternal immune stimulation during pregnancy affects adaptive immunity in offspring to promote development of TH17 cells

@article{Mandal2011MaternalIS,
  title={Maternal immune stimulation during pregnancy affects adaptive immunity in offspring to promote development of TH17 cells},
  author={Mili Mandal and Atara C Marzouk and R Donnelly and Nicholas M. Ponzio},
  journal={Brain, Behavior, and Immunity},
  year={2011},
  volume={25},
  pages={863-871}
}
Behavioral abnormalities in offspring of murine dams that receive immune stimulation with (poly)I:C during pregnancy are well-documented. In this prenatal model, (poly)I:C-induced maternal cytokines, particularly IL-6, appear involved in the etiology of the behavioral abnormalities. While much has been published on the abnormal behaviors of offspring in this model, much less is known about how maternal immune stimulation affects the adaptive immune system of the offspring, and its possible role… CONTINUE READING

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