Maternal immune activation promotes hippocampal kindling epileptogenesis in mice.

  title={Maternal immune activation promotes hippocampal kindling epileptogenesis in mice.},
  author={Eduardo A. Pineda and Don Shin and Su Jeong You and St{\'e}phane Auvin and R Ramesh Sankar and Andr{\'e}y M. Mazarati},
  journal={Annals of neurology},
  volume={74 1},
OBJECTIVE Maternal immune activation (MIA) triggered by infections has been identified as a cause of autism in offspring. Considering the involvement of perturbations in innate immunity in epilepsy, we examined whether MIA represents a risk factor for epilepsy as well. The role of specific MIA components interleukin (IL)-6 and IL-1β was also addressed. METHODS MIA was induced in C57BL/6 mice by polyinosinic-polycytidylic acid (PIC) injected during embryonic days 12 to 16. Beginning from… CONTINUE READING


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Maternal immune activation in neurodevelopmental disorders.

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