Maternal immune activation and abnormal brain development across CNS disorders

  title={Maternal immune activation and abnormal brain development across CNS disorders},
  author={Irene Knuesel and Laurie Chicha and Markus Britschgi and Scott A. Schobel and Michael Bodmer and Jessica A. Hellings and Stephen Toovey and Eric P. Prinssen},
  journal={Nature Reviews Neurology},
Epidemiological studies have shown a clear association between maternal infection and schizophrenia or autism in the progeny. Animal models have revealed maternal immune activation (mIA) to be a profound risk factor for neurochemical and behavioural abnormalities in the offspring. Microglial priming has been proposed as a major consequence of mIA, and represents a critical link in a causal chain that leads to the wide spectrum of neuronal dysfunctions and behavioural phenotypes observed in the… CONTINUE READING
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