Maternal immune activation and abnormal brain development across CNS disorders

@article{Knuesel2014MaternalIA,
  title={Maternal immune activation and abnormal brain development across CNS disorders},
  author={Irene Knuesel and Laurie Chicha and Markus Britschgi and Scott A. Schobel and Michael Bodmer and Jessica A. Hellings and Stephen Toovey and Eric P. Prinssen},
  journal={Nature Reviews Neurology},
  year={2014},
  volume={10},
  pages={643-660}
}
Epidemiological studies have shown a clear association between maternal infection and schizophrenia or autism in the progeny. Animal models have revealed maternal immune activation (mIA) to be a profound risk factor for neurochemical and behavioural abnormalities in the offspring. Microglial priming has been proposed as a major consequence of mIA, and represents a critical link in a causal chain that leads to the wide spectrum of neuronal dysfunctions and behavioural phenotypes observed in the… CONTINUE READING
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Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring

  • Bauman, D M.
  • Biol. Psychiatry
  • 2014

Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition

  • K Zavitsanou
  • Brain Behav. Immun
  • 2014

Efficacy of anti-inflammatory agents to improve symptoms in patients with schizophrenia: an update

  • Sommer, E I.
  • Schizophr. Bull. 40,
  • 2014

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