Maternal immune activation alters fetal brain development through interleukin-6.

@article{Smith2007MaternalIA,
  title={Maternal immune activation alters fetal brain development through interleukin-6.},
  author={Stephen E. P. Smith and Jennifer Li and Krassimira A. Garbett and Karoly Mirnics and Paul H. Patterson},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 40},
  pages={10695-702}
}
Schizophrenia and autism are thought to result from the interaction between a susceptibility genotype and environmental risk factors. The offspring of women who experience infection while pregnant have an increased risk for these disorders. Maternal immune activation (MIA) in pregnant rodents produces offspring with abnormalities in behavior, histology, and gene expression that are reminiscent of schizophrenia and autism, making MIA a useful model of the disorders. However, the mechanism by… CONTINUE READING
Highly Influential
This paper has highly influenced 54 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 434 extracted citations

Maternal immune activation alters brain microRNA expression in mouse offspring

Annals of clinical and translational neurology • 2018
View 5 Excerpts
Highly Influenced

Impact of prenatal environmental stress on cortical development

Front. Cell. Neurosci. • 2015
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 79 references

The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2006
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…