Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3‐year follow‐up study

@article{Pop2003MaternalHD,
  title={Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3‐year follow‐up study},
  author={V. Pop and E. Brouwers and H. Vader and T. Vulsma and A. Van Baar and J. de Vijlder},
  journal={Clinical Endocrinology},
  year={2003},
  volume={59}
}
objective To evaluate the impact of maternal hypothyroxinaemia during early gestation (fT4 below the lowest tenth percentile and TSH within the reference range: 0·15–2·0 mIU/l) on infant development, together with any subsequent changes in fT4 during gestation. 
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References

SHOWING 1-10 OF 33 REFERENCES
Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy
Maternal thyroid function during early pregnancy is an important determinant of early fetal brain development because the fetal thyroid is unable to produce any T4 before 12–14 weeks' gestation.Expand
Maternal Hypothyroidism and Fetal Development
TLDR
The relation between maternal and fetal iodine deficiency and the child's retardation has long been recognized, but the fetal thyroid gland does not have a role in this condition. Expand
Thyroid function in the newborn in relation to maternal thyroid status during labour in a mild iodine deficiency endemic area in Sudan
TLDR
This study focuses on elucidating the thyroid function during labour, in a group of pregnant women who live in an area of mild iodine deficiency in Sudan compared to that observed in their corresponding newborns. Expand
Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia?
TLDR
It is proposed that the screening of pregnant women for thyroid disorders should include the determination of free T4 as soon as possible during the first trimester as a major test, because hypothyroxinemia has been related to poor developmental outcome, irrespective of the presence of high titers of thyroid autoantibodies or elevated serum TSH. Expand
Maternal Thyroid Deficiency During Pregnancy and Subsequent Neuropsychological Development of the Child
TLDR
It may be worthwhile to routinely screen for hypothyroidism in early pregnancy and testing at the first prenatal visit and prompt follow-up of those with positive results would permit timely treatment and could prevent adverse neuropsychological effects during early child development. Expand
Thyroid hormones and neurodevelopment
TLDR
Low maternal plasma fT4 concentrations during early pregnancy may be an important risk factor for impaired infant development. Expand
Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child.
TLDR
Undiagnosed hypothyroidism in pregnant women may adversely affect their fetuses; therefore, screening for thyroid deficiency during pregnancy may be warranted. Expand
Maternal thyroid peroxidase antibodies during pregnancy: a marker of impaired child development?
TLDR
It is concluded that children of pregnant women who had elevated titers of TPO-Ab but normal thyroid function are at risk for impaired development. Expand
Maternal and fetal thyroid function.
TLDR
In this article, recent data and new insights regarding the changes in thyroid metabolism are reviewed and the role of the placenta and amniotic fluid in these changes is reviewed. Expand
Thyroid function in human pregnancy. IX. Development or retardation of 7-year-old progeny of hypothyroxinemic women.
TLDR
In six sibling sets outcome was better when hypothyroxinemic women were treated with adequate thyroid replacement therapy, and if a woman has a poor reproductive history, early in a subsequent gestation, thyroid status should be examined and adequate thyroid medication considered seriously. Expand
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