Maternal human leukocyte antigen A*2301 is associated with increased mother-to-child HIV-1 transmission.

@article{Mackelprang2010MaternalHL,
  title={Maternal human leukocyte antigen A*2301 is associated with increased mother-to-child HIV-1 transmission.},
  author={Romel D Mackelprang and Mary Carrington and Grace John-Stewart and Barbara Lohman-Payne and Barbra Ann Richardson and Dalton C. Wamalwa and Xiaojiang Gao and Maxwel Majiwa and Dorothy Mbori-Ngacha and Carey Farquhar},
  journal={The Journal of infectious diseases},
  year={2010},
  volume={202 8},
  pages={1273-7}
}
We examined associations between maternal human leukocyte antigen (HLA) and vertical human immunodeficiency virus type 1 (HIV-1) transmission in a perinatal cohort of 277 HIV-infected women in Nairobi. HLA class I genes were amplified by using sequence-specific oligonucleotide probes, and analyses were performed using logistic regression. Maternal HLA-A*2301 was associated with increased transmission risk before and after adjusting for maternal viral load (unadjusted: odds ratio [OR], 3.21; 95… CONTINUE READING
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