Maternal homocysteine in pregnancy and offspring birthweight: epidemiological associations and Mendelian randomization analysis.

@article{Yajnik2014MaternalHI,
  title={Maternal homocysteine in pregnancy and offspring birthweight: epidemiological associations and Mendelian randomization analysis.},
  author={Chittaranjan Yajnik and Giriraj Ratan Chandak and Charudatta Vaman Joglekar and Prachi Pramod Katre and Dattatray S Bhat and Suraj N Singh and Charles Spurgeon Janipalli and Helge Refsum and G V Krishnaveni and Sargoor R. Veena and Clive Osmond and Caroline Fall},
  journal={International journal of epidemiology},
  year={2014},
  volume={43 5},
  pages={
          1487-97
        }
}
BACKGROUND Disturbed one-carbon (1-C) metabolism in the mother is associated with poor fetal growth but causality of this relationship has not been established. METHODS We studied the association between maternal total homocysteine and offspring birthweight in the Pune Maternal Nutrition Study (PMNS, Pune, India) and Parthenon Cohort Study (Mysore, India). We tested for evidence of causality within a Mendelian randomization framework, using a methylenetetrahydrofolatereductase (MTHFR) gene… CONTINUE READING

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Commentary: One-carbon metabolism has major implications for fetal growth and development beyond neural tube defects.

  • International journal of epidemiology
  • 2014
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CITES METHODS & BACKGROUND
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Confessions of a thin-fat Indian

  • European Journal of Clinical Nutrition
  • 2017
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