Maternal high-fat intake alters presynaptic regulation of dopamine in the nucleus accumbens and increases motivation for fat rewards in the offspring.

@article{Naef2011MaternalHI,
  title={Maternal high-fat intake alters presynaptic regulation of dopamine in the nucleus accumbens and increases motivation for fat rewards in the offspring.},
  author={Lindsay Naef and Luc Moquin and Gr{\'e}gory Dal Bo and Bruno Giros and Alain P Gratton and C Walker},
  journal={Neuroscience},
  year={2011},
  volume={176},
  pages={225-36}
}
High caloric intake during early postnatal development can have long term consequences for the offspring. We previously reported that the adult offspring of dams fed a high-fat diet during the last week of gestation and throughout lactation display blunted locomotor response to amphetamine (AMP) and reduced sensitization to the drug compared to offspring of control diet dams. Here, we report that the subsensitivity of high-fat offspring to AMP's locomotor stimulant action reflects, at least in… CONTINUE READING
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