Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes.

@article{Vucetic2010MaternalHD,
  title={Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes.},
  author={Zivjena Vucetic and Jessica N Kimmel and Kathy Totoki and Emily Hollenbeck and Teresa M Reyes},
  journal={Endocrinology},
  year={2010},
  volume={151 10},
  pages={4756-64}
}
Maternal obesity during pregnancy increases the risk of obesity in the offspring. Obesity, arising from an imbalance of energy intake and expenditure, can be driven by the ingestion of palatable [high fat (HF), high sugar], energy-dense foods. Dopamine and opioid circuitry are neural substrates associated with reward that can affect animals' preference for palatable foods. Using a mouse model, the long-term effect of maternal consumption of a HF diet on dopamine and opioid gene expression… CONTINUE READING