Maternal-fetal glucocorticoid milieu programs hypothalamic-pituitary-thyroid function of adult offspring.

@article{SloneWilcoxon2004MaternalfetalGM,
  title={Maternal-fetal glucocorticoid milieu programs hypothalamic-pituitary-thyroid function of adult offspring.},
  author={Jennifer Slone-Wilcoxon and Eva E Redei},
  journal={Endocrinology},
  year={2004},
  volume={145 9},
  pages={4068-72}
}
To assess the role of maternal glucocorticoid milieu on the hypothalamic-pituitary-thyroid function of the offspring, we adrenalectomized (ADX) pregnant dams on gestation d 8 and implanted a placebo pellet or a continuous release 50- or 75-mg corticosterone (CORT) pellet. Maternal ADX led to realignment of the balance between maternal and fetal plasma CORT levels, resulting in an increase in CORT of fetal origin in the maternal compartment. Maternal ADX and low levels of CORT replacement had no… CONTINUE READING
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