Maternal-fetal disposition of bisphenol a in pregnant Sprague-Dawley rats.

  title={Maternal-fetal disposition of bisphenol a in pregnant Sprague-Dawley rats.},
  author={Beom Soo Shin and Sun Dong Yoo and Chang Youn Cho and Ji Hoon Jung and Byung Mu Lee and Jung Ha Kim and Kang Choon Lee and Soon-Young Han and Hyung Sik Kim and Kui Lea Park},
  journal={Journal of toxicology and environmental health. Part A},
  volume={65 5-6},
This study describes the maternal-fetal disposition of bisphenol A and its distribution into the placenta and amniotic fluid after iv injection (2 mg/kg) to pregnant Sprague-Dawley rats. Bisphenol A was distributed extensively to the placenta and fetus, with their respective AUC values 4.4- and 2.2-fold greater than AUC for the maternal serum. In contrast, the distribution of bisphenol A into the amniotic fluid was low, with the mean amniotic fluid-to-maternal serum AUC ratio of 0.2. The decay… CONTINUE READING

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