Maternal exposure to the antiepileptic drug vigabatrin affects postnatal development in the rat

@article{Lombardo2005MaternalET,
  title={Maternal exposure to the antiepileptic drug vigabatrin affects postnatal development in the rat},
  author={Salvatore Andrea Lombardo and Giampiero Leanza and Concetta Meli and Maria Elena Lombardo and Luigi Mazzone and Ilena Vincenti and Matteo Cioni},
  journal={Neurological Sciences},
  year={2005},
  volume={26},
  pages={89-94}
}
The objective was to investigate, in the rat, the effects of maternal exposure to vigabatrin (VGB) on the postnatal motor-cognitive behaviour of the offspring. We used an experimental evaluator-blind, placebo-controlled study in the rat. Ten pregnant rats were divided into five groups and treated with different doses of VGB (250, 500, 750, 1000 mg/kg/day) or placebo from gestation day (GD) 6 to GD10. After delivery, 56 pups (40 pups prenatally exposed to VGB and 16 pups exposed to placebo) were… Expand
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