Maternal exposure to procymidone has no effects on fetal external genitalia development in male rabbit fetuses in a modified developmental toxicity study.

@article{Inawaka2010MaternalET,
  title={Maternal exposure to procymidone has no effects on fetal external genitalia development in male rabbit fetuses in a modified developmental toxicity study.},
  author={Kunifumi Inawaka and Noriyuki Kishimoto and Hashihiro Higuchi and Satoshi Kawamura},
  journal={The Journal of toxicological sciences},
  year={2010},
  volume={35 3},
  pages={
          299-307
        }
}
This study was conducted to evaluate the effects of procymidone (PCM) on development of male rabbit fetal external genitalia. PCM was administered once daily by gavage at dose levels of 0 (control) and 125mg/kg/day to pregnant rabbits from gestation day 6 through 28 and fetal external genitalia was observed in detail. This treatment period covered the critical stage of sexual differentiation of fetal external genitalia in rabbits. In the maternal animals, food consumption was reduced in the PCM… 

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References

SHOWING 1-9 OF 9 REFERENCES
Effects of perinatal exposure to flutamide on sex hormones and androgen-dependent organs in F1 male rats.
TLDR
This study indicates that the most sensitive parameter is AGD, whereby reduction was observed at 2.5 mg/kg and above in this perinatal study of an antiandrogenic chemical.
New method for detecting antiandrogenic effects through the measurement of external genitalia in rabbits
TLDR
A quantitative evaluation method for detecting antiandrogenic activity of chemicals in rabbits that are regularly used for developmental toxicity studies was developed and the lower fetal BW in CA‐treated males did not disturb the detection of the feminization of the ventral gap of the preputial lamella.
Critical developmental periods for effects on male rat genitalia induced by finasteride, a 5 alpha-reductase inhibitor.
TLDR
It is hypothesize that finasteride causes hypospadias by preventing the formation of the medial mesenchymal plate which is necessary for assisting the movement of the urogenital sinus from the base to the tip of the genital tubercle.
Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat.
TLDR
Pregnant exposure to finasteride specifically inhibited DHT-mediated development with little to no change in T- mediated development and was highly predictive of hypospadias, ectopic testes, and prostate malformations even though some animals with retained nipples or decreased AGD may not have had other reproductive tract malforms.
The affinity of procymidone to androgen receptor in rats and mice.
TLDR
Results indicate that procymidone is an active antiandrogen and the androgen receptor antagonism is the likely mechanism of action.
The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro
TLDR
The antiandrogenic activity of procymidone was demonstrated in vivo and in vitro in cell lines transfected with hAR and appears to be slightly less potent in inducing malformations than vinclozolin by a factor of about two.
Comparative Metabolism of Procymidone in Rats and Mice
TLDR
The drug’s potential uses are still unclear, but it is likely to have an important role in the treatment of cancer.